Tested and working using wine 1.0rc2
What works?
Everything except it may not look all perfect due to compression issues.
Activates perfectly
games play unless they are compressed
Projects can be opened and saved without issue
All tools as of Wine 1.0rc1 work e.g. face maker and all... Dynamic Linking of tools like calc and placement work...
As always having windows inside of a virtual machine works best!
Scripting works flawlessly!

Depending on the distribution of choice you may run into issues
Known issues.
1. Game may freeze the computer and needs to be restarted. This is due to the RPGVX.exe file being super compressed.(working on this)
2. Music may not work depending on the distro. You must enable ALSA audio and emulate driver. Midi files may not produce sound but ogg wav mp3 are all supported fully.
WARNING: Do not check all three audio options wine will not run!
3. Text may display incorrectly or not at all. You must have the Microsoft core fonts installed.
4. Menu crashed X11 and a critical error occurs. This is due to the RPGVX.exe file being compressed. Trying to work through the dlls needed. This does not happen on 64 bit versions of Linux only on 32. Once I have fully gotten it to work I will post a link to working non-microsoft DLL files and a list of the files used for the time being. Stay tuned for updates!
Level of completion 98%
F.A.Q.
Why work so hard to get it to work under Linux as there are much better apps needing porting?
I am a fanboy of the RPG Maker Series simple as that.


Will the games made with the windows version work too?
Only if you include any external dlls you may have called when scripting out using ruby.
Only if the game is not compressed as this causes lag issues and may cause X11 to lockup.

Instructions:
1. Go here and according to the distribution you use install wine1.0rc2 http://www.winehq.org/site/download
NOTE:Using 0.9.x may not work with any RPG Maker or may give really wierd results.
2. Click through your applications menu until you find wine>configure wine after it is done installing. Run winecfg from the terminal if it doesn't put it into your menu.
3. Click the audio tab and make sure all only 1 of the 3 boxes are checked. Set the Audio acceleration to full for now unless you don't get music. You may have to play around with these settings until you get music. Ubuntu especially has an issue as it compresses the sound to make it more compatible and this causes with the audio being pre-compressed and midi files don't play.
4. Install the RTP and the RMVX programs as you would windows. If the installation freezes in such as the XWareM2 release wait like a minute save all of your work and hit CTRL+ALT+BACKSPACE and login. Create a launcher link to /home/username/.wine/drive_c/Program Files/Enterbrain/RPG Maker VX/RPGVX.exe I am going to extract the Icon file and post it to the download section soon unless someone already has and all.
WARNING:I don't condone pirating software and I use the XWareM2 release because I hate registering the darned thing every time I install it on one of my PC's. I purchased the Japanese and English versions respectively and have the Japanese version box sealed. Support such a great program and buy at least the English version 60 bucks is not that much.
UPDATE:
Wine 1.0rc2 is out. I will supply downloads to hacked DLL files once the final release comes out to suppliment the menu bug!
Face Maker doesn't read any of the face png files yet on my todo list. once again a dll error.
XY Machine works 100%
RMXP Calculator works 100%
Move Event does not work and simply crashes out.
I am not going to test the loaders as they are useless now.
Crossover office works quite well and doesn't crash X due to the menu error and there will be instructions for those who need it later with hacked DLL files.
I need help and need to know what outside Windows DLL files RPG Maker VX calls and could I get someone like Hyperlisk or Elemental Crisis to let me know so I can edit the open source ones to mimic the Windows ones more closely! I am extremely close to completion and this would be a huge help and once I am done I will post them in the download section with instructions!
Below is a screen-shot:
(IMG:http://i213.photobucket.com/albums/cc250/rabbitnightmare/RPGMakerrunninginUbuntu.png)

I tried this, and yet I get an error upon attempting to use the database. See my thread in the RPG Maker Support for more details please! I didn't see this thread beforehand.